The drive from Houston to Lake Charles is entirely on Interstate 10. Golden Nugget Hotel & Casino Lake Charles Also, there are a few slot-machine only casinos a little closer, but the Houstonian looking for a traditional full gambling experience will have to travel to Lake Charles, Louisiana, 143 miles from downtown Houston. Visitors and residents to America’s 4th largest city will have to travel a bit if they want to scratch their gambling itch, as the closest casino to Houston is 143 miles away.Īnd here were talking about real public casinos, with slot machines, table games, sportsbooks, restaurants, entertainment venues and the like.